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Department Of Pharmaceutical Chemistry

The vast majority of the drugs used in treatment are synthetic or semi-synthetic molecules. The pharmacological effect of a drug is the function of its chemical structure. Therefore, in the process that begins with synthesis of a drug, progresses with formulation and application to human body and ends with extraction, Pharmaceutical Chemistry investigates chemical procedure of the synthesis, qualitative and quantitative analysis, chemical properties of drugs, and the close relationships between their pharmacokinetic and pharmacodynamic features with chemical structure. Pharmaceutical Chemistry evaluates those findings to develop new drugs as its main goal. Each branch of science has a utopia. The utopia of Pharmaceutical Chemistry is to reach the ideal drug molecule with selective and specific action without any side effects.

Therefore, the purpose of the Pharmaceutical Chemistry courses offered by the Department of Pharmaceutical Chemistry is to provide theoretical and practical knowledge and skills necessary to understand all aspects of synthetic or semi-synthetic drugs.

In graduate studies offering M.S. degree and Ph.D. degree respectively, more detailed studies in Pharmaceutical Chemistry are programmed to prepare graduate students for advanced professional studies as well as academic, industrial or research fields.

The Research Fıelds

Design, synthesis, structure identifications, bioactivity studies and structure-activity relationships of potentially bioactive molecules
Computer-Aided Drug Design
Quantitative Drug Analysis

Undergraduate Courses
Organic Chemistry I

The aim of the course
In this course, carbon chemistry is studied in detail. The organic chemistry I course begins with the geometry of carbon bonds; continues with the nomenclature, synthesis, reactions and identifications of the functional groups such as hydrocarbons (alkane, alkene, alkyn), halogenated organic compounds, alcohols, phenols and ethers.

Topics:
1. Basic principles of Organic Chemistry
2. Nomenclature of Organic Compounds
3. Functional Groups
3.1. Alkanes
3.2. Alkenes
3.3. Alkynes
3.4. Alkyl halides
3.5. Alcohols and Phenols
3.6. Ethers

Organıc Chemıstry II

The aim of the course:
Organic chemistry II course examines nomenclature, synthesis, reactions and identifications of the functional groups such as aldehydes, ketones, carboxylic acides, carboxylic acide derivatives and amines. Meanwhile, a brief introduction to heterocyclic organic chemistry is also made. In the last part of organic chemistry course, the basic aspects of Stereochemistry are mentioned. The main goal of the course is to provide basic organic chemistry knowledge necessary for the whole pharmaceutical sciences.

Topics:
1. Functional Groups
1.1. Aldehydes and Ketones
1.2. Carboxylic Acids and Carboxylic Acid Derivatives
1.3. Amines
2. Introduction to Heterocyclic Chemistry
3. Stereochemistry

Pharmaceutıcal Chemıstry I

The aim of the course:In Pharmaceutical Chemistry I course, drug design and development is examined. For this purpose, parameters used to form quantitative structure-activity relationships, physicochemical factors determining the drug action, drug-receptor interactions and theories and drug metabolism pathways are studied. Basic principles of computer-aided drug design are also examined.

Topics:
1. Introduction to Medicinal Chemistry and Basic Principles
2. Quantative Structure Activity Relationship
3. Bioisosterism
4. Drug Metabolism
5. Carrier Systems and Retrometabolic Drug Design
6. Receptors and Drug-Receptor Interactions
7. Introduction to Computer-Aided Drug Design

Applıed Pharmaceutıcal Chemıstry I
The aim of the course:
In the course of Applied Pharmaceutical Chemistry I, synthesis of organic compounds used as drugs or intermediates in drug synthesis is carried out. The aim is to acquire basic concepts about organic synthesis and to increase the skills and knowledge in laboratory studies.

Pharmaceutıcal Chemıstry II
The aim of the course:
The aim of the course is to discuss synthesis, qualitative structure-activity relationships, metabolisms, quantitative analysis, therapeutic actions, side effects and drug interactions of synthetic and semi-synthetic drugs in detail. With this purpose, Autonomic Nervous System Drugs, Cardiovascular System Drugs, Antihistaminics, Antidiabetics, Gastro-Intestinal System Drugs and Local Anesthetics are studied.

Topics:
1. Autonomic Nervous System Drugs
2. Antiparkinson Drugs
3. Cardiovascular System Drugs
4. Antihypertensive Drugs
5. Ca+ Channel Blockers
6. ACE Inhibitors
7. Angiotensin Receptor Blockers
8. Peripheral Vasodilator Drugs
9. Antianginal Drugs
10. Antiarrhythmic Drugs
11. Antihyperlipidemic Drugs and Fibrates
12. Anticoagulant Drugs
13. Antithrombotic Drugs
14. Diuretic Drugs
15. Local Anesthetics

Applıed Pharmaceutıcal Chemıstry II
The aim of the course:
Qualitative analyzes of drugs are carried out according to conventional organic analysis methods. Demonstrative information is given about chromatographic and qualitative spectral analyzes.

Pharmaceutıcal Chemıstry III
The aim of the course:
The aim of the course is to discuss synthesis, qualitative structure-activity relationships, metabolisms, quantitative analysis, therapeutic actions, side effects and drug interactions of synthetic and semi-synthetic drugs in detail. Within the scope of Central Nervous System Drugs and Chemotherapeutics; Antiseptics, Disinfectants, Antituberculosis Drugs and Sulfonamides are studied.

Topics:
1. Central Nervous System Drugs
1.1. Sedative and Hypnotic Drugs
1.2. General Anesthesia Drugs
1.3. Muscle Relaxants
1.4. Neuroleptics
1.5. Antiepileptic Drugs
1.6. Analgesics
1.7. Anti-inflammatory Drugs
1.8. Uricosuric Drugs
1.9. Analeptics
1.10. Psychostimulants
1.11. Antidepressants
1.12. MAO Inhibitors
2. Chemotherapeutics
2.1. Antiseptics and Disinfectants
2.2. Urinary Antiseptic Drugs
2.3. Tuberculostatic Drugs
2.4. Leprostatic Drugs
2.5. Antibacterial Sulfonamides and Quinolones

Applıed Pharmaceutıcal Chemıstry III
The aim of the course:
Volumetric and spectrophotometric quantitative assays as well as pharmacopoeia analysis of various drugs are carried out.

Pharmaceutıcal Chemıstry IV
The aim of the course:
The aim of the course is to discuss synthesis, qualitative structure-activity relationships, metabolisms, quantitative analysis, therapeutic actions, side effects and drug interactions of synthetic and semi-synthetic drugs in detail. With this purpose chemotherapeutics including Antibiotics, Antifungal Drugs, Antiviral Drugs, Antiparasitic Drugs, Antihelmintic Drugs and Antineoplastic Drugs fallowed by Hormones and Vitamins are studied.
Topics:
1. Antibiotics
2. Antifungal Drugs
3. Antiviral Drugs
4. Antiprotozoal Drugs
5. Antihelmintics
6. Anticancer Therapy
6.1. Alkylating Agents
6.2. Antimetabolite Drugs
6.3. Anticancer Hormones and Antibiotics
7. Hormones
7.1. Steroid and Nonsteroid Gonadal Hormones
7.2. Thyroid Hormones
8. Vitamins

Pharmaceutıcal Chemıstry IV
The aim of the course:
Applications of modern spectroscopic methods used for qualitative analysis of drugs and qualitative multicomponent analysis are studied.

Academic Staff

Prof. Dr. Varol PABUÇÇUOĞLU (Head of Department)
Prof. Dr. Vildan ALPTÜZÜN
Prof. Dr. Zeynep SOYER
Assoc. Prof. Dr. Özlem AKGÜL
Assist. Prof. Dr. Ayşe Hande TARİKOĞULLARI DOĞAN
Res. Asst. Dr. Murat ÇİZMECİOĞLU
Res. Asst. Dr. Güneş ÇOBAN
Res. Asst. Dr. Sülünay PARLAR
Res. Asst. Dr. Şirin UYSAL
Res. Asst. Dr. Görkem FİDAN
Res. Asst. Gülşah BAYRAKTAR
Res Asst. Dr. Çiğdem YENGİN

 


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